St. Paul, one of the "twin cities" of Minneapolis-St. Paul, is the capital of Minnesota. It is the second largest city in Minnesota, behind Minneapolis, with a population of over 275,000 people. The Twin Cities metropolitan statistical area has a population of nearly 3 million people according to U.S. Census Bureau estimates.St. Paul is located on the Mississippi River, which separates it from Minneapolis, in eastern Minnesota, near the Wisconsin border. The Twin Cities are home to almost 20 Fortune 1000 company headquarters, seven of which are in St. Paul.